Primary Identifier | MGI:3625874 | Allele Type | QTL |
Gene | Lmr17 | Inheritance Mode | Other (see notes) |
Strain of Origin | CcS20/Dem | Is Recombinase | false |
Is Wild Type | false |
description | Lmr17 exhibits additive inheritance. Lmr17 interacts with Lmr3 on chromosome 5 to influence serum IFN-gamma levels. F2 animals homozygous for BALB/cHeA-derived alleles at Lrm3 and STS/A-derived alleles at Lrm17 exhibit higher serum IFN-gamma concentrations. |
molecularNote | STS/A alleles at this locus were associated with increased levels of TNF alpha in serum. Homozygous BALB/c alleles at Lmr24f and homozygous STS/A alleles at Lmr17 (D9Mit2) increase IFN gmma levels. |