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Allele : Ar<tm3(AR)Dmr> androgen receptor; targeted mutation 3, Diane M Robins

Primary Identifier  MGI:3628492 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Ar
Transmission  Germline Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  Human androgen receptor amino acids 31 to 484 were inserted into the mouse locus. This allele contains 48 glutamine residues in the N terminal. Transient cre expression removed a floxed neo from the recombined locus. RT-PCR demonstrated higher levels of transcript in mutants than wild-type. Western blot showed that protein levels were also somewhat higher.
  • mutations:
  • Insertion
  • synonyms:
  • AR48Q,
  • Ar<tm3Apl>,
  • 48Q,
  • AR48Q,
  • Ar<tm3Apl>,
  • 48Q
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

10 Publication categories