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Allele : Tg(Camk2a-Prkaca)426Tabe transgene insertion 426, Ted Abel

Primary Identifier	MGI:3626071	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Camk2a-Prkaca)426Tabe
Strain of Origin	(C57BL/6J x CBA/J)F2	Is Recombinase	false
Is Wild Type	false

molecularNote

The cAMP-dependent protein kinase A (PKA or PRKACA) RIalpha regulatory subunit, R(AB), was mutated at both cAMP binding sites and placed under control of the mouse Camk2a promoter.

mutations:
Insertion

synonyms:
R(AB),
CaMKII-R(AB),
CaMKII-R(AB),
R(AB)-2,
R(AB)-2,
R(AB)

earliestPublication:
Abel T, et al. (1997) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88(5):615-26

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

12 Publication categories

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