Primary Identifier | MGI:3628446 | Allele Type | Targeted |
Attribute String | Humanized sequence, Hypomorph | Gene | Dnmt3b |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to insert an A609T substitution, replicating the A603T mutation found in some human ICF syndrome patients. Cre mediated recombination removed a floxed IRES-betageo from the locus. This allele produced protein at levels similar to those of wild-type mice. |