| Primary Identifier | MGI:3628614 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Ptgs2 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An A to T base change was introduced into exon 8 which caused the substitution of tyrosine, residue 385, with phenylalanine (Y385F). Numbering is based on numbering for the sheep protein. The actual mouse modification is Y371F. A floxed neomycin resistance cassette was introduced in intron 9. The cyclooxygenase function was inactivated but not the peroxidase function. |
