| Primary Identifier | MGI:3626350 | Allele Type | Chemically induced (ENU) |
| Gene | Kcnj8 | Inheritance Mode | Recessive |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| description | The mutation was identified as a result of immunocompromise observed in progeny of ENU-mutagenized mice during infection with mouse cytomegalovirus (MCMV). Mice carrying this mutation show higher susceptibility than that observed in susceptible BALB/c mice. |
| molecularNote | Slumber mice exhibit the same phenotype as mayday mice, which contain a mutation in Kcnj8. Although they arose in distinct pedigrees, complementation testing indicated that slumber is allelic with mayday. Sequencing revealed that the slumber allele contains the same mutation as the mayday allele. The mutation in Kcnj8 consists of a deletion of exon 1 and most of exon 2, due to their replacement by an inverted segment of intron 2. |
