| Primary Identifier | MGI:3630259 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Il2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A green fluorescent protein (GFP) cDNA was inserted into the first exon such that the endogenous promoter directs expression of GFP. An adjacent selectable marker was removed by cre-mediated recombination in ES cells prior to the production of chimeric mice. Expression of GFP was shown to mimic endogenous Il2 gene expression in both a temporal and spatial manner; induction experiments also showed that GFP expression was triggered by costimulatory signals similar to the endogenous gene. |
