| First Author | Jochum W | Year | 2000 |
| Journal | Nat Med | Volume | 6 |
| Issue | 9 | Pages | 980-4 |
| PubMed ID | 10973316 | Mgi Jnum | J:64494 |
| Mgi Id | MGI:1889415 | Doi | 10.1038/79676 |
| Citation | Jochum W, et al. (2000) Increased bone formation and osteosclerosis in mice overexpressing the transcription factor fra-1. Nat Med 6(9):980-4 |
| abstractText | Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions. |
