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Allele : Tg(Myh6-Akt1)564Anr transgene insertion 564, Anthony Rosenzweig

Primary Identifier	MGI:3639127	Allele Type	Transgenic
Attribute String	Constitutively active, Inserted expressed sequence	Gene	Tg(Myh6-Akt1)564Anr
Is Recombinase	false	Is Wild Type	false

molecularNote

This transgene expresses a constitutively active mutant of Akt1 (the Akt1 cDNA contains a Src myristoylation signal) under the control of the mouse alpha-myosin heavy chain promoter. The transgene is expressed in the heart and at low levels in the lung but not in kidney or skeletal muscle.

mutations:
Insertion

synonyms:
TG564,
TG564

earliestPublication:
Matsui T, et al. (2002) Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 277(25):22896-901

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

5 Publication categories

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