| First Author | Zhao J | Year | 2013 |
| Journal | Biomed Res Int | Volume | 2013 |
| Pages | 848265 | PubMed ID | 24319691 |
| Mgi Jnum | J:310738 | Mgi Id | MGI:6763761 |
| Doi | 10.1155/2013/848265 | Citation | Zhao J, et al. (2013) Changes in Otx2 and parvalbumin immunoreactivity in the superior colliculus in the platelet-derived growth factor receptor-beta knockout mice. Biomed Res Int 2013:848265 |
| abstractText | The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and beta subunit of receptors of platelet-derived growth factor (PDGFR- beta ) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR- beta -knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR- beta KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR- beta KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR- beta KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR- beta KO mice. These findings suggest that PDGFR- beta plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively. |
