| First Author | Akbar SM | Year | 1999 |
| Journal | Biochem Biophys Res Commun | Volume | 259 |
| Issue | 2 | Pages | 294-9 |
| PubMed ID | 10362501 | Mgi Jnum | J:55942 |
| Mgi Id | MGI:1339807 | Doi | 10.1006/bbrc.1999.0776 |
| Citation | Akbar SM, et al. (1999) Unique features of dendritic cells in IFN-gamma transgenic mice: relevance to cancer development and therapeutic implications. Biochem Biophys Res Commun 259(2):294-9 |
| abstractText | Although induction of interferon gamma (IFN-gamma) and activation of antigen presenting dendritic cells (DCs) are two vital events during an immune response, the impact of endogenous IFN-gamma on DC function has yet to be clarified. The phenotype and function of DCs isolated from mice with high (IFN-gamma-transgenic mouse [Tg]) and undetectable levels of circulating IFN-gamma (normal mice [NM]) were therefore compared. The capacity to stimulate allogenic (p < 0.05) and antigen-specific T lymphocytes (p < 0.05), as well as the ability to produce IL-12 (p < 0.05) and to process soluble protein antigens (p < 0.05) was found to be significantly higher in DCs from the Tg mice compared to the NM case. The presence of activated DCs in a microenvironment of endogenous IFN-gamma suggests that the IFN-gamma-Tg mouse is a suitable animal model to study cancer immunotherapy in vivo. Copyright 1999 Academic Press. |
