| First Author | Zou X | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 3 | Pages | 1354-61 |
| PubMed ID | 12538695 | Mgi Jnum | J:118712 |
| Mgi Id | MGI:3700237 | Doi | 10.4049/jimmunol.170.3.1354 |
| Citation | Zou X, et al. (2003) Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain. J Immunol 170(3):1354-61 |
| abstractText | Silencing individual C (constant region) lambda genes in a kappa(-/-) background reduces mature B cell levels, and L chain-deficient (lambda(-/-)kappa(-/-)) mice attain a complete block in B cell development at the stage when L chain rearrangement, resulting in surface IgM expression, should be completed. L chain deficiency prevents B cell receptor association, and L chain function cannot be substituted (e.g., by surrogate L chain). Nevertheless, precursor cell levels, controlled by developmental progression and checkpoint apoptosis, are maintained, and B cell development in the bone marrow is fully retained up to the immature stage. L chain deficiency allows H chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal. |
