| First Author | Tilley MR | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 11 | Pages | 1137-40 |
| PubMed ID | 18596615 | Mgi Jnum | J:137820 |
| Mgi Id | MGI:3803027 | Doi | 10.1097/WNR.0b013e3283063183 |
| Citation | Tilley MR, et al. (2008) Dopamine transporter inhibition is required for cocaine-induced stereotypy. Neuroreport 19(11):1137-40 |
| abstractText | The primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (DAT), norepinephrine, and serotonin. To dissect out the role of DAT in cocaine effects, we generated a knock-in mouse line with a cocaine-insensitive DAT (DAT-CI mice). DAT-CI mice provide a powerful tool that can directly test whether DAT inhibition is important for cocaine-induced stereotypy. We found that acute cocaine failed to produce stereotypy in DAT-CI mice. In fact, 40 mg/kg cocaine suppressed stereotypy in DAT-CI mice but produced profound stereotypy in wild-type mice. These findings suggest that DAT inhibition is necessary for cocaine-induced stereotypy. Furthermore, mechanisms independent of DAT inhibition appear to inhibit stereotypy. |
