Primary Identifier | MGI:3656034 | Allele Type | Targeted |
Attribute String | Hypomorph | Gene | Ptch2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin selection cassette was inserted into exon 6. Northern blot and RT-PCR analysis indicated that aberrant in-frame splice transcripts lacking exon 6, exons 5 and 6 or exons 6 and 7 are expressed from this allele. Mutant proteins with partial function are predicted to be expressed suggesting that this allele is a hypomorph. |