| First Author | Lin JZ | Year | 2018 |
| Journal | Cell Rep | Volume | 23 |
| Issue | 7 | Pages | 1977-1987 |
| PubMed ID | 29768198 | Mgi Jnum | J:270867 |
| Mgi Id | MGI:6278328 | Doi | 10.1016/j.celrep.2018.04.057 |
| Citation | Lin JZ, et al. (2018) Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis. Cell Rep 23(7):1977-1987 |
| abstractText | Adipose tissue fibrosis is associated with inflammation and insulin resistance in human obesity. In particular, visceral fat fibrosis is correlated with hyperlipidemia and ectopic fat accumulation. Myocardin-related transcription factor A (MRTFA) is an important coactivator that mediates the transcription of extracellular matrix and other fibrogenic genes. Here, we examine the role of MRTFA in the development of adipose tissue fibrosis and identify a signaling pathway that regulates the fate of vascular progenitors. We demonstrate that obesity induces the formation of Sca1(-), Sma(+), ITGA5(+) fibrogenic progenitor cells (FPCs) in adipose tissue. MRTFA deficiency in mice shifts the fate of perivascular progenitors from FPCs to adipocyte precursor cells and protects against chronic obesity-induced fibrosis and accompanying metabolic dysfunction, without a shift in energy expenditure. Our findings highlight the ITGA5-MRTFA pathway as a potential target to ameliorate obesity-associated metabolic disease. |
