| First Author | Peterson EJ | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5538 | Pages | 2263-5 |
| PubMed ID | 11567141 | Mgi Jnum | J:111368 |
| Mgi Id | MGI:3653815 | Doi | 10.1126/science.1063486 |
| Citation | Peterson EJ, et al. (2001) Coupling of the TCR to integrin activation by Slap-130/Fyb. Science 293(5538):2263-5 |
| abstractText | SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals. |
