Primary Identifier | MGI:3664449 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence, Null/knockout | Gene | Igkc |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to insert the human IGKC and a neo cassette such that the sequence containing a splice signal and 12 base pairs of endogenous sequence were replaced. The remainder of the locus was rendered nonfunctional. Flow cytometry demonstrated the expression of humanized proteins on B cell surfaces. |