| First Author | Röll S | Year | 2006 |
| Journal | Matrix Biol | Volume | 25 |
| Issue | 6 | Pages | 373-81 |
| PubMed ID | 16806869 | Mgi Jnum | J:111767 |
| Mgi Id | MGI:3654818 | Doi | 10.1016/j.matbio.2006.05.004 |
| Citation | Roll S, et al. (2006) Testican-1 is dispensable for mouse development. Matrix Biol 25(6):373-81 |
| abstractText | Testicans are proteoglycans belonging to the BM-40/SPARC/osteonectin family of extracellular calcium-binding proteins. Testican-1 is strongly expressed in the brain and has been reported to modulate neuronal attachment and matrix metalloproteinase activation. Characterization of the mouse testican-1 gene (Ticn1), consisting of 12 exons out of which exon 3 is alternatively spliced, allowed the construction of a gene targeting construct. Mice deficient in testican-1 showed no obvious morphological or behavioral abnormalities, were fertile, and had normal life spans. Despite the fact that neither of the testican-1 homologues expressed in the brain, testican-2, testican-3 and SC1/hevin, showed an increased expression in Ticn1 null mice, these results, together with those from other gene targetings, indicate extensive functional redundancy among brain proteoglycans. |
