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Allele : Rock1<tm1Liao> Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, James K Liao

Primary Identifier	MGI:3665285	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Rock1
Transmission	Germline	Strain of Origin	C57BL/6
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1b was removed via cre-mediated recombination, resulting in a frame shift that created a stop codon in exon 1c, preventing translation of the functional protein.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
Rock1<->,
Rock I<->,
Rock I<->,
Rock1<->

earliestPublication:
Rikitake Y, et al. (2005) Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation 111(24):3261-8

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

16 Publication categories

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