| First Author | Hu Y | Year | 2025 |
| Journal | Cell Rep | Volume | 44 |
| Issue | 1 | Pages | 115086 |
| PubMed ID | 39708317 | Mgi Jnum | J:361840 |
| Mgi Id | MGI:7864791 | Doi | 10.1016/j.celrep.2024.115086 |
| Citation | Hu Y, et al. (2025) Dissociation-related behaviors in mice emerge from the inhibition of retrosplenial cortex parvalbumin interneurons. Cell Rep 44(1):115086 |
| abstractText | Dissociation, characterized by altered consciousness and perception, underlies multiple mental disorders, but the specific neuronal subtypes involved remain elusive. In mice, we find that dissociation-inducing doses of ketamine significantly inhibit retrosplenial cortex (RSC) parvalbumin interneurons (PV-INs), enhancing delta oscillations (1-3 Hz) and delta-gamma phase-amplitude coupling (delta-gamma PAC) and inducing dissociation-like behaviors. Optogenetic inhibition of RSC PV-INs triggers delta oscillations, delta-gamma PAC, and some dissociation-like behaviors without ketamine. Furthermore, activation of RSC PV-INs or knockdown of the N-methyl-D-aspartate receptor subunit NR1 and the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) in RSC PV-INs attenuates ketamine-induced delta oscillations, delta-gamma PAC, and certain dissociation-like behaviors. These findings reveal that PV-INs regulate delta oscillations and delta-gamma PAC and identify NR1 and HCN1 as ketamine targets in PV-INs that may cooperatively affect dissociation, possibly providing potential therapeutic targets for dissociative symptoms. |
