| First Author | Hao YE | Year | 2015 |
| Journal | FEBS Open Bio | Volume | 5 |
| Pages | 688-704 | PubMed ID | 26380813 |
| Mgi Jnum | J:259620 | Mgi Id | MGI:6148136 |
| Doi | 10.1016/j.fob.2015.08.005 | Citation | Hao YE, et al. (2015) GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice. FEBS Open Bio 5:688-704 |
| abstractText | G protein-coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein-coupled receptors (GPCRs). The short-splice form of GIT2 is expressed in peripheral T cells and thymocytes. However, the functions of GIT2 in T cells have not yet been determined. We show that treatment with Con A in a model of polyclonal T-lymphocyte activation resulted in marked inhibitions in the intrahepatic infiltration of inflammatory cells, cytokine response and acute liver failure in Git2 (-/-) mice. CD4(+) T cells from Git2 (-/-) mice showed significant impairment in proliferation, cytokine production and signal transduction upon TCR-stimulated activation. Our results suggested that GIT2 plays an important role in T-cell function in vivo and in vitro. |
