| First Author | Thomas M | Year | 2007 |
| Journal | Blood | Volume | 109 |
| Issue | 8 | Pages | 3342-50 |
| PubMed ID | 17179224 | Mgi Jnum | J:145338 |
| Mgi Id | MGI:3834323 | Doi | 10.1182/blood-2006-09-046698 |
| Citation | Thomas M, et al. (2007) Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation. Blood 109(8):3342-50 |
| abstractText | How diverse environmental cues are integrated to regulate B-cell activation and development remains poorly understood. Here we show that Notch activity synergizes with B-cell receptor (BCR) and/or CD40 signaling to enhance several aspects of B-cell activation and function. We find that costimulation of follicular B cells with the Notch ligand Delta-like-1 leads to significant increases in BCR- and CD40-mediated proliferation and enhances production of IgG1(+) cells in vitro and in vivo. We further find that coengagement of Notch and the BCR results in increased activation of the MAPK pathway, and MAPK and Notch inhibitors prevent B-cell activation events mediated by coengagement of Notch and the BCR. These data suggest that the BCR and CD40 signaling pathways collaborate with the Notch pathway to optimize B-cell activation. |
