| First Author | Wang P | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 10 | Pages | 912-9 |
| PubMed ID | 20818395 | Mgi Jnum | J:164686 |
| Mgi Id | MGI:4834965 | Doi | 10.1038/ni.1933 |
| Citation | Wang P, et al. (2010) Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol 11(10):912-9 |
| abstractText | Caspase-12 has been shown to negatively modulate inflammasome signaling during bacterial infection. Its function in viral immunity, however, has not been characterized. We now report an important role for caspase-12 in controlling viral infection via the pattern-recognition receptor RIG-I. After challenge with West Nile virus (WNV), caspase-12-deficient mice had greater mortality, higher viral burden and defective type I interferon response compared with those of challenged wild-type mice. In vitro studies of primary neurons and mouse embryonic fibroblasts showed that caspase-12 positively modulated the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I, a critical signaling event for the type I interferon response to WNV and other important viral pathogens. |
