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Allele : Tg(Myh6-Myl2*)21Rbns transgene insertion 21, Jeffrey Robbins
Primary Identifier  MGI:3688749 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Myh6-Myl2*)21Rbns
Is Recombinase  false Is Wild Type  false
molecularNote  This transgene consists of the full-length adult mouse (BALB/c) ventricular isoform of Myl2 (regulatory myosin light chain 2) with serines 14, 15, and 19 each mutated and replaced by alanine, under the control of the murine alpha-myosin heavy chain promoter. Replacing the three serines with alanines results in a nonphosphorylatable Myl2. Examination of atrial myofibrillar protein composition shows a progressive replacement of the atrial isoform with the mutated ventricular form as mice age.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(Myh6-Mylpf*)21Rbns,
  • Tg(Myh6-Mylpf*)21Rbns,
  • TG-RLC(P-),
  • RLC2v(P-),
  • TG-RLC(P-),
  • RLC2v(P-)
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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