Primary Identifier | MGI:3687023 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(HLA-DQA1,HLA-DQB1)73Myl |
Strain of Origin | B6.129S2-H2-Ab1<b-tm1Gru> | Is Recombinase | false |
Is Wild Type | false |
description | Three separate lines were generated: 70, 73, and 275. Lines 73 and 275 differed primarily in severity of phenotype, with 73 being more severe than 275. |
molecularNote | The 13.4 kb DQA1*301 and 19.9 kb DQB1*302 genes were subcloned into the pWE15 cosmid. The 33.3 kb fragment was purified and injected into fertilized eggs from H2Ab1tm1Gru on the C57BL/6 background. |