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Allele : Tg(HLA-DQA1,HLA-DQB1)73Myl transgene insertion 73, Myra A Lipes

Primary Identifier  MGI:3687023 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(HLA-DQA1,HLA-DQB1)73Myl
Strain of Origin  B6.129S2-H2-Ab1<b-tm1Gru> Is Recombinase  false
Is Wild Type  false
description  Three separate lines were generated: 70, 73, and 275. Lines 73 and 275 differed primarily in severity of phenotype, with 73 being more severe than 275.
molecularNote  The 13.4 kb DQA1*301 and 19.9 kb DQB1*302 genes were subcloned into the pWE15 cosmid. The 33.3 kb fragment was purified and injected into fertilized eggs from H2Ab1tm1Gru on the C57BL/6 background.
  • mutations:
  • Insertion
  • synonyms:
  • HLA-DQ8,
  • HLA-DQ8,
  • HLA-DQ8 line 73,
  • HLA-DQ8 line 73
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1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

3 Publication categories