| First Author | Fang YY | Year | 2018 |
| Journal | Neuron | Volume | 98 |
| Issue | 1 | Pages | 192-207.e10 |
| PubMed ID | 29621487 | Mgi Jnum | J:260437 |
| Mgi Id | MGI:6150619 | Doi | 10.1016/j.neuron.2018.02.019 |
| Citation | Fang YY, et al. (2018) A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors. Neuron 98(1):192-207.e10 |
| abstractText | Maternal behaviors are essential for the survival of the young. Previous studies implicated the medial preoptic area (MPOA) as an important region for maternal behaviors, but details of the maternal circuit remain incompletely understood. Here we identify estrogen receptor alpha (Esr1)-expressing cells in the MPOA as key mediators of pup approach and retrieval. Reversible inactivation of MPOA(Esr1+) cells impairs those behaviors, whereas optogenetic activation induces immediate pup retrieval. In vivo recordings demonstrate preferential activation of MPOA(Esr1+) cells during maternal behaviors and changes in MPOA cell responses across reproductive states. Furthermore, channelrhodopsin-assisted circuit mapping reveals a strong inhibitory projection from MPOA(Esr1+) cells to ventral tegmental area (VTA) non-dopaminergic cells. Pathway-specific manipulations reveal that this projection is essential for driving pup approach and retrieval and that VTA dopaminergic cells are reliably activated during those behaviors. Altogether, this study provides new insight into the neural circuit that generates maternal behaviors. |
