| First Author | Habib N | Year | 2020 |
| Journal | Nat Neurosci | Volume | 23 |
| Issue | 6 | Pages | 701-706 |
| PubMed ID | 32341542 | Mgi Jnum | J:293161 |
| Mgi Id | MGI:6445844 | Doi | 10.1038/s41593-020-0624-8 |
| Citation | Habib N, et al. (2020) Disease-associated astrocytes in Alzheimer's disease and aging. Nat Neurosci 23(6):701-706 |
| abstractText | The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer's disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors. |
