| First Author | Ano Y | Year | 2017 |
| Journal | J Biol Chem | Volume | 292 |
| Issue | 9 | Pages | 3720-3728 |
| PubMed ID | 28087694 | Mgi Jnum | J:241388 |
| Mgi Id | MGI:5901985 | Doi | 10.1074/jbc.M116.763813 |
| Citation | Ano Y, et al. (2017) Iso-alpha-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer's Disease. J Biol Chem 292(9):3720-3728 |
| abstractText | Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long, healthy life. Here we found that iso-alpha-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor gamma. In normal mice, oral administration of iso-alpha-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain. In Alzheimer's model 5xFAD mice, oral administration of iso-alpha-acids resulted in a 21% reduction in amyloid beta in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1beta and chemokines including macrophage inflammatory protein-1alpha in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice. The differences in iso-alpha-acid-fed mice were due to the induction of microglia to an anti-inflammatory phenotype. The present study is the first to report that amyloid beta deposition and inflammation are suppressed in a mouse model of Alzheimer's disease by a single component, iso-alpha-acids, via the regulation of microglial activation. The suppression of neuroinflammation and improvement in cognitive function suggests that iso-alpha-acids contained in beer may be useful for the prevention of dementia. |
