| First Author | Dos Santos Guilherme M | Year | 2020 |
| Journal | Front Microbiol | Volume | 11 |
| Pages | 1008 | PubMed ID | 32508799 |
| Mgi Jnum | J:352659 | Mgi Id | MGI:7704284 |
| Doi | 10.3389/fmicb.2020.01008 | Citation | Dos Santos Guilherme M, et al. (2020) Impact of Acute and Chronic Amyloid-beta Peptide Exposure on Gut Microbial Commensals in the Mouse. Front Microbiol 11:1008 |
| abstractText | Alzheimer's disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in model mice and in patients, but the reported data are still highly inconsistent. Therefore, we investigated chronic effects of AD-characteristic neurotoxic amyloid-beta (Abeta) peptides as provided by transgenic overexpression (5xFAD mouse model) and acute effects due to oral application of Abeta on gut microbes. Astonishingly, one-time feeding of wild type mice with Abeta(42) provoked immediate changes in gut microbiome composition (beta diversity) as compared to controls. Such obvious changes were not observed when comparing 5xFAD mice with wild type littermates. However, acute as well as chronic exposure to Abeta significantly affected the abundance of numerous individual operational taxonomic units. This provides first evidence that acute in vivo exposure to Abeta results in a shift in the enteric microbiome. Furthermore, we suggest that chronic exposure to Abeta might trigger an adaptive response of gut microbiota which could thereby result in dysbiosis in model mice but also in human patients. |
