| First Author | Zhang C | Year | 2021 |
| Journal | Neuron | Volume | 109 |
| Issue | 3 | Pages | 461-472.e5 |
| PubMed ID | 33278342 | Mgi Jnum | J:307177 |
| Mgi Id | MGI:6707192 | Doi | 10.1016/j.neuron.2020.11.010 |
| Citation | Zhang C, et al. (2021) Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron 109(3):461-472.e5 |
| abstractText | Nausea, the unpleasant sensation of visceral malaise, remains a mysterious process. The area postrema is implicated in some nausea responses and is anatomically privileged to detect blood-borne signals. To investigate nausea mechanisms, we built an area postrema cell atlas through single-nucleus RNA sequencing, revealing a few neuron types. Using mouse genetic tools for cell-specific manipulation, we discovered excitatory neurons that induce nausea-related behaviors, with one neuron type mediating aversion imposed by multiple poisons. Nausea-associated responses to agonists of identified area postrema receptors were observed and suppressed by targeted cell ablation and/or gene knockout. Anatomical mapping revealed a distributed network of long-range excitatory but not inhibitory projections with subtype-specific patterning. These studies reveal the basic organization of area postrema nausea circuitry and provide a framework toward understanding and therapeutically controlling nausea. |
