| First Author | Iliev ID | Year | 2012 |
| Journal | Science | Volume | 336 |
| Issue | 6086 | Pages | 1314-7 |
| PubMed ID | 22674328 | Mgi Jnum | J:184826 |
| Mgi Id | MGI:5426445 | Doi | 10.1126/science.1221789 |
| Citation | Iliev ID, et al. (2012) Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 336(6086):1314-7 |
| abstractText | The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease. |
