| First Author | Soares ER | Year | 1979 |
| Journal | Environ Mutagen | Volume | 1 |
| Issue | 1 | Pages | 19-25 |
| PubMed ID | 162283 | Mgi Jnum | J:6450 |
| Mgi Id | MGI:54926 | Doi | 10.1002/em.2860010108 |
| Citation | Soares ER (1979) TEM-induced gene mutations at enzyme loci in the mouse. Environ Mutagen 1(1):19-25 |
| abstractText | Strain DBA/2J male mice were treated with triethylenemelamine (TEM) and subsequently mated to strain C57BL/6J females. Tissues from F1 progeny produced in these crosses were then examined using starch gel electrophoresis for the presence of presumed induced mutations at a series of 11 specific enzyme loci. In the course of this study, four heritable mutations were identified at the following loci: Es-1, Ldh-1, Pgm-1, and Gpi-1. Of these four, the first two were apparently segregating in parental males and were not TEM-induced. Both of these are viable and fertile in the heterozygous and homozygous condition, and neither confers any readily apparent deleterious effect to the animal. The latter mutations (Pgm-1 and Gpi-1) are presumably induced. Although viable and fertile in the heterozygous state, we have not recovered any offsping homozygous for either of these two mutations. |
