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Transgene : Tg(Nlrp1b)1Die transgene insertion 1, William Dietrich
Primary Identifier  MGI:3695918 Organism  mouse, laboratory
Chromosome  UN Mgi Type  transgene
description  PHENOTYPE: Expression of the 129S1/SvImJ Nlrp1b transgene makes macrophages susceptible to necrosis induced by anthrax lethal toxin (LeTx), even when the strain background is normally resistant (B6, SJL, NOD, DBA/2J). The BAC also contains the 129S1 Nlrp1c gene, but this is a pseudogene and is not expressed. [provided by MGI curators]
  • synonyms:
  • transgene insertion 1, William Dietrich,
  • Nlrp1b<129S1>,
  • Nalp1b<129S1>,
  • Tg(CT7-336A14)1Die,
  • Tg(Nlrp1b)1Die
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