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Allele : Tg(Lck-ZAP70)824Saka transgene insertion 824, Shimon Sakaguchi

Primary Identifier	MGI:3698650	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Lck-ZAP70)824Saka
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

Expression of human ZAP70 is controlled by the Lck proximal promoter. Thymocytes and peripheral T cells express the transgene.

mutations:
Insertion

earliestPublication:
Sakaguchi N, et al. (2003) Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 426(6965):454-60

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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