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Allele : Tg(Tcra172,Tcrb172)1Wcl transgene insertion 1, Warren C Ladiges

Primary Identifier	MGI:3699517	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Tcra172,Tcrb172)1Wcl
Strain of Origin	(SWR x DBA/1LacJ)F1	Is Recombinase	false
Is Wild Type	false

molecularNote

Rearranged Valpha11.1 and Vbeta8.2 TCR chain genes including the endogenous promoter regions were isolated from Type II collagen-specific T-cell hybridoma 172 and then were ligated together. The resulting single construct was used to generate transgenic mice.

mutations:
Insertion

earliestPublication:
Osman GE, et al. (1998) Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice. Int Immunol 10(11):1613-22

1 Feature

Genome

2 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

5 Publication categories

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