|  Help  |  About  |  Contact Us

Publication : Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

First Author  Juste YR Year  2021
Journal  Nat Cell Biol Volume  23
Issue  12 Pages  1255-1270
PubMed ID  34876687 Mgi Jnum  J:321050
Mgi Id  MGI:6860497 Doi  10.1038/s41556-021-00800-z
Citation  Juste YR, et al. (2021) Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol 23(12):1255-1270
abstractText  Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here we show a functional interplay between the circadian clock and chaperone-mediated autophagy (CMA), whereby CMA contributes to the rhythmic removal of clock machinery proteins (selective chronophagy) and to the circadian remodelling of a subset of the cellular proteome. Disruption of this autophagic pathway in vivo leads to temporal shifts and amplitude changes of the clock-dependent transcriptional waves and fragmented circadian patterns, resembling those in sleep disorders and ageing. Conversely, loss of the circadian clock abolishes the rhythmicity of CMA, leading to pronounced changes in the CMA-dependent cellular proteome. Disruption of this circadian clock/CMA axis may be responsible for both pathways malfunctioning in ageing and for the subsequently pronounced proteostasis defect.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

10 Bio Entities

0 Expression