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Allele : Sox10<tm3(Sox8)Weg> SRY (sex determining region Y)-box 10; targeted mutation 3, Michael Wegner

Primary Identifier	MGI:3701358	Allele Type	Targeted
Gene	Sox10	Transmission	Germline
Strain of Origin	129P2/OlaHsd	Is Recombinase	false
Is Wild Type	false

molecularNote

The Sox8 open reading frame along with an IRES-EGFP and a floxed neo cassette were inserted into exon 3, replacing the entire open reading frame of Sox10. The neo cassette was removed via in vivo Cre mediated recombination.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Sox10<Sox8ki>,
Sox10<Sox8ki>

earliestPublication:
Kellerer S, et al. (2006) Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development 133(15):2875-86

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

5 Publication categories

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