| First Author | Zhao Z | Year | 2019 |
| Journal | J Cell Physiol | Volume | 234 |
| Issue | 11 | Pages | 20790-20800 |
| PubMed ID | 31037731 | Mgi Jnum | J:289222 |
| Mgi Id | MGI:6434687 | Doi | 10.1002/jcp.28685 |
| Citation | Zhao Z, et al. (2019) Transcription factor 7-like 2-associated signaling mechanism in regulating cementum generation by the NF-kappaB pathway. J Cell Physiol 234(11):20790-20800 |
| abstractText | Cementum regeneration is an important and challenging stage in periodontal tissue engineering and regeneration. Pathosis of the periodontium, including cementum, is important in precision diagnosis and obstinate treatment of systemic diseases, such as diabetes, leukemia, and Acquired Immune Deficiency Syndrome. Here, we found that during periodontium development, transcription factor 7-like 2 (Tcf7l2) was widely expressed in the periodontium and dental sac. In mouse cementoblast cell line (OCCM-30), the activation of NF-kappaB and cementoblast mineralization was significantly reduced when Tcf7l2 gene was silenced. Moreover, Tcf7l2 has a positive effect on NF-kappaB and cementoblast mineralization. Therefore, Tcf7l2 promotes cementum formation through the NF-kappaB pathway. In addition, we found a decreased expression of phosphorylated p65 and a thin layer of cementum in Tcf7l2(fl/fl) mice. These results suggest that Tcf7l2, which accelerates cementum formation by activating NF-kappaB, has great potential in the treatment of periodontitis and provide guidance for periodontal tissue regeneration. |
