| First Author | Zhang J | Year | 2016 |
| Journal | Cell Rep | Volume | 16 |
| Issue | 2 | Pages | 405-18 |
| PubMed ID | 27346349 | Mgi Jnum | J:238517 |
| Mgi Id | MGI:5822965 | Doi | 10.1016/j.celrep.2016.05.083 |
| Citation | Zhang J, et al. (2016) IkappaB Kinase epsilon Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep 16(2):405-18 |
| abstractText | Activation of nuclear factor of activated T cells (NFAT) is crucial for immune responses. IKKepsilon is an IkappaB kinase (IKK)-related kinase, and the function of IKKepsilon remains obscure in T cells, despite its abundant expression. We report that IKKepsilon inhibits NFAT activation and T cell responses by promoting NFATc1 phosphorylation. During T cell activation, IKKepsilon was transiently activated to phosphorylate NFATc1. Loss of IKKepsilon elevated T cell antitumor and antiviral immunity and, therefore, reduced tumor development and persistent viral infection. IKKepsilon was activated in CD8(+) T cells of mice bearing melanoma or persistently infected with a model herpesvirus. These results collectively show that IKKepsilon promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy. |
