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Publication : Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

First Author  Mamalaki C Year  1992
Journal  Proc Natl Acad Sci U S A Volume  89
Issue  23 Pages  11342-6
PubMed ID  1360667 Mgi Jnum  J:120505
Mgi Id  MGI:3706706 Doi  10.1073/pnas.89.23.11342
Citation  Mamalaki C, et al. (1992) Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc Natl Acad Sci U S A 89(23):11342-6
abstractText  Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.
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