| First Author | Kosaki N | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 354 |
| Issue | 4 | Pages | 846-51 |
| PubMed ID | 17275784 | Mgi Jnum | J:120352 |
| Mgi Id | MGI:3706304 | Doi | 10.1016/j.bbrc.2006.12.234 |
| Citation | Kosaki N, et al. (2007) Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun 354(4):846-51 |
| abstractText | Vascular and cellular invasion into the cartilage is a critical step in the fracture healing. Matrix metalloproteinase-13 (MMP-13) is a member of the zinc-dependent endopeptidase family and plays an important role in remodeling of extracellular matrix. Therefore we investigated the possible involvement of MMP-13 in a murine model of stabilized bone fracture healing. Repair of the fracture in MMP-13 deficient (MMP-13(-/-)) mice was significantly delayed and characterized by a retarded cartilage resorption in the fracture callus. Immunohistochemistry indicated severe defects in vascular penetration and chondroclast recruitment to the fracture callus in MMP-13(-/-) mice. Consistent with the observations, the chondrocyte pellets cultured from the MMP13(-/-) mice exhibited diminished angiogenic activities when the pellets were co-cultured with endothelial cells. These results suggest that MMP-13 is crucial to the process of angiogenesis during healing of fracture, especially in the cartilage resorption process. |
