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Allele : Tg(tetO-APPSwInd)18Dbo transgene insertion 18, David R Borchelt
Primary Identifier  MGI:3709065 Allele Type  Transgenic
Attribute String  Humanized sequence, Inducible, Inserted expressed sequence Gene  Tg(tetO-APPSwInd)18Dbo
Strain of Origin  (C57BL/6J x C3H/HeJ)F1 Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(tetO-APP*Swe*Ind)18Dbo,
  • Tg(tetO-APP*Swe*Ind)18Dbo,
  • tet-APPswe/ind line 18,
  • tet-APPswe/ind line 18
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

1 Driven By

3 Publication categories





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