| First Author | Davis SR | Year | 2007 |
| Journal | Cancer Cell | Volume | 11 |
| Issue | 4 | Pages | 305-7 |
| PubMed ID | 17418406 | Mgi Jnum | J:120956 |
| Mgi Id | MGI:3708421 | Doi | 10.1016/j.ccr.2007.03.016 |
| Citation | Davis SR, et al. (2007) Modeling synovial sarcoma: timing is everything. Cancer Cell 11(4):305-7 |
| abstractText | Synovial sarcoma is characterized by the presence of a fusion protein involving SYT and SSX2. In this issue of Cancer Cell, Haldar et al. have genetically engineered a mouse model of this disease. They show that expression of the SYT-SSX2 fusion gene yields a highly penetrant and representative model of human synovial sarcoma, but only if expression occurs in a particular biologic context. The mouse model will be a valuable resource for studying tumor biology but is also a striking example of how important understanding of normal tissue and developmental biology is to our understanding of cancer. |
