| First Author | Ranganathan P | Year | 2012 |
| Journal | Blood | Volume | 119 |
| Issue | 20 | Pages | 4786-97 |
| PubMed ID | 22408260 | Mgi Jnum | J:184986 |
| Mgi Id | MGI:5427035 | Doi | 10.1182/blood-2011-10-387522 |
| Citation | Ranganathan P, et al. (2012) Regulation of acute graft-versus-host disease by microRNA-155. Blood 119(20):4786-97 |
| abstractText | Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplant (alloHSCT), underscoring the need to further elucidate its mechanisms and develop novel treatments. Based on recent observations that microRNA-155 (miR-155) is up-regulated during T-cell activation, we hypothesized that miR-155 is involved in the modulation of aGVHD. Here we show that miR-155 expression was up-regulated in T cells from mice developing aGVHD after alloHSCT. Mice receiving miR-155-deficient donor lymphocytes had markedly reduced lethal aGVHD, whereas lethal aGVHD developed rapidly in mice recipients of miR-155 overexpressing T cells. Blocking miR-155 expression using a synthetic anti-miR-155 after alloHSCT decreased aGVHD severity and prolonged survival in mice. Finally, miR-155 up-regulation was shown in specimens from patients with pathologic evidence of intestinal aGVHD. Altogether, our data indicate a role for miR-155 in the regulation of GVHD and point to miR-155 as a novel target for therapeutic intervention in this disease. |
