| First Author | Chen G | Year | 2007 |
| Journal | Mol Cell Biol | Volume | 27 |
| Issue | 8 | Pages | 3109-22 |
| PubMed ID | 17283041 | Mgi Jnum | J:121380 |
| Mgi Id | MGI:3709934 | Doi | 10.1128/MCB.01014-06 |
| Citation | Chen G, et al. (2007) The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol 27(8):3109-22 |
| abstractText | 3BP2 is a pleckstrin homology domain- and Src homology 2 (SH2) domain-containing adapter protein that is mutated in the rare human bone disorder cherubism and which has also been implicated in immunoreceptor signaling. However, a function for this protein has yet to be established. Here we show that mice lacking 3BP2 exhibited a perturbation in the peritoneal B1 and splenic marginal-zone B-cell compartments and diminished thymus-independent type 2 antigen response. 3BP2(-/-) B cells demonstrated a proliferation defect in response to antigen receptor cross-linking and a heightened sensitivity to B-cell receptor-induced death via a caspase-3-dependent apoptotic pathway. We show that 3BP2 binds via its SH2 domain to the CD19 signaling complex and is required for optimum Syk phosphorylation and calcium flux. |
