| First Author | Virtue S | Year | 2018 |
| Journal | Cell Rep | Volume | 24 |
| Issue | 8 | Pages | 2005-2012.e7 |
| PubMed ID | 30134163 | Mgi Jnum | J:270406 |
| Mgi Id | MGI:6278397 | Doi | 10.1016/j.celrep.2018.07.063 |
| Citation | Virtue S, et al. (2018) Peroxisome Proliferator-Activated Receptor gamma2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Cell Rep 24(8):2005-2012.e7 |
| abstractText | One understudied function of white adipose tissue (AT) is its role in postprandial lipid buffering. In this study, we demonstrate that mice lacking the adipose tissue-specific transcription factor peroxisome proliferator-activated receptor gamma2 (PPARgamma2) exhibit a defect in their rate of adipose tissue lipid storage. Impaired adipose tissue storage rate reduces metabolic flexibility, without compromising fasted glucose tolerance or insulin sensitivity, even following prolonged high-fat feeding. However, acutely overfeeding PPARgamma2-KO mice caused a 10-fold increase in insulin levels compared with controls. Although impaired adipose tissue storage rate did not result in insulin resistance in young mice, 1-year-old PPARgamma2-KO mice developed skeletal muscle insulin resistance. Our data indicate that failed adipose tissue storage may occur prior to defects in glucose handling and that overfeeding protocols may uncover genes controlling adipose tissue storage rate, as opposed to capacity, and act as a diagnostic test for early-stage human metabolic disease. |
