Primary Identifier | MGI:3712927 | Allele Type | Chemically induced (ENU) |
Gene | Otof | Inheritance Mode | Recessive |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | ENU treatment caused a T-to-A substitution in exon 10, changing isoleucine codon 318 (ATC) to asparagine (AAC) (c.953T>A, p.I318N). The encoded amino-acid is a highly conserved residue of the C2B protein domain and immunohistochemistry of the cochlea fails to detect this protein. |