| First Author | Lawlor KT | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 30676318 | Mgi Jnum | J:275948 |
| Mgi Id | MGI:6304063 | Doi | 10.7554/eLife.41156 |
| Citation | Lawlor KT, et al. (2019) Nephron progenitor commitment is a stochastic process influenced by cell migration. Elife 8:e41156 |
| abstractText | Progenitor self-renewal and differentiation is often regulated by spatially restricted cues within a tissue microenvironment. Here, we examine how progenitor cell migration impacts regionally induced commitment within the nephrogenic niche in mice. We identify a subset of cells that express Wnt4, an early marker of nephron commitment, but migrate back into the progenitor population where they accumulate over time. Single cell RNA-seq and computational modelling of returning cells reveals that nephron progenitors can traverse the transcriptional hierarchy between self-renewal and commitment in either direction. This plasticity may enable robust regulation of nephrogenesis as niches remodel and grow during organogenesis. |
