| First Author | Horikawa R | Year | 2022 |
| Journal | Neurosci Lett | Volume | 790 |
| Pages | 136895 | PubMed ID | 36191793 |
| Mgi Jnum | J:330380 | Mgi Id | MGI:7366808 |
| Doi | 10.1016/j.neulet.2022.136895 | Citation | Horikawa R, et al. (2022) Effects of peripheral administration of lipopolysaccharide on chronic sickness responses in TRPM8-deficient mice. Neurosci Lett 790:136895 |
| abstractText | Transient receptor potential melastatin 8 (TRPM8) is a cold-sensing thermoreceptor cation channel; however, its functional role in endotoxin-induced neuroinflammation remains unclear. In the present study, we investigated chronic sickness responses in TRPM8 knockout (KO) mice during lipopolysaccharide (LPS)-induced sepsis. The intraperitoneal administration of 5 mg/kg LPS generated longer-lasting hypothermia in TRPM8 KO mice than in wild-type (WT) mice. TRPM8 KO mice also exhibited longer-lasting declines in locomotor activity, body weight, and food and water intakes than WT mice upon LPS administration. In addition, LPS-induced decreases in the numbers of leucocytes and lymphocytes that persisted for a longer time in TRPM8 KO mice than in WT mice. The present results indicate TRPM8 attenuated chronic sickness responses in endotoxin-induced sepsis. |
