| First Author | Safory H | Year | 2015 |
| Journal | EMBO Rep | Volume | 16 |
| Issue | 5 | Pages | 590-8 |
| PubMed ID | 25755256 | Mgi Jnum | J:222873 |
| Mgi Id | MGI:5645847 | Doi | 10.15252/embr.201439561 |
| Citation | Safory H, et al. (2015) The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission. EMBO Rep 16(5):590-8 |
| abstractText | Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders. |
